Step 1 : Introduction to the question "Which first name is unique among U.S. First Ladies?"
...The only U.S. First Lady named Lucy was Lucy Hayes, wife of President Rutherford B. Hayes. Serving from 1877 to 1881 during the post–Civil War Reconstruction era, she was known for her strong moral convictions and for supporting her husband’s decision to ban alcohol from White House functions, earning her the nickname “Lemonade Lucy.” By contrast, Abigail (Adams and Fillmore), Edith (Roosevelt and Wilson), Martha (Washington and Jefferson Randolph), and Elizabeth (Monroe and Ford) all appear more than once in First Lady history.
