[Answer] What substance released from damaged endothelium triggers the extrinsic coagulation pathway? prothrombin activator platelet factor 3 (PF3) prostacyclin tissue factor (TF) or factor III

Answer: tissue factor (TF) or factor III

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What substance released from damaged endothelium triggers the extrinsic coagulation pathway? prothrombin activator platelet factor 3 (PF3) prostacyclin tissue factor (TF) or factor III Clotting factors are proteins that upon changing shape at activation become enzymes that can further activate another clotting factor in the reaction cascade . What substance released from damaged endothelium triggers the extrinsic coagulation pathway? PF3 ( platelet factor 3) substance produced by activated platelets that acts similarly to tissue factor in activating various clotting factors involved in formation of prothrombin activator (c) Once fibrin threads formed thrombin & Ca2+ ions activate Fibrin Stabilizing Factor - clotting factor released by platelets that binds fibrin threads tightly together & strengthens clot The pathway of blood coagulation activated by tissue factor a protein extrinsic to blood is known as the extrinsic pathway (Figure 1). Tissue factor serves as a cofactor with factor VII to facilitate the activation of factor X. Alternatively factor VII can activate factor IX which in turn can activate factor X. Once activated factor X proceeds to activate prothrombin to thrombin in a reaction requiring factor V. Sun Jan 29 2017 · How is the intrinsic pathway of coagulation activated by? ... B. Activation of proenzymes exposed to collagen. C. Release of tissue factor ( Factor III ) by damaged endothelium . D. Release of heparin from the liver. E. Conversion of prothrombin to thrombin. This question is … Prothrombin factor 1.2 is released (see common pathway) After initial activation pathway is inhibited by the binding of tissue factor pathway inhibitor (TFPI) to factor Xa which inhibits TF-Factor VIIa complex and further coagulation is dependent on the intrinsic pa...

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