Answer: An error in cell division that causes homologous chromosomes or sister chromatids to move to the same side of the dividing cell
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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate properly during cell division. There are three forms of nondisjunction: failure of a pair of homologous chromosomes to separate in meiosis I failure of sister chromatids to separate during meiosis II and failure of sister chromatids to separate during mitosis.
Nondisjunction results in daughter cells with abnormal chromosome numbers (aneuploidy). Calvin Bridges and Thomas Hunt Morgan are credited with discovering nondisjunction in Drosophila melanogaster sex chromosomes in the spring of 1910 while working in the Zoological Laboratory of Columbia University.
Nondisjunction produces abnormal numbers of both AUTOSOMES (e.g. DOWN'S SYNDROME) and SEX CHROMOSOMES (e.g. TURNERS SYNDROME). Nondisjunction A genetic term referring to an event which takes place during cell division in which a genetic accident causes an egg or sperm cell to have 24 chromosomes rather than the normal 23.
Wed Jan 25 2017 · Medical Definition of Nondisjunction. Nondisjunction: Failure of paired chromosomes to separate (to disjoin) during cell division so that both chromos...
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