[Answer] Why is it sometimes difficult to identify causative genes using traditional linkage analysis?

Answer: -Late onset disease--difficult to obtain multiple generations.-incomplete penetrance-progression of disease is very rapid-difficult to obtain DNA samples.-results in numerous genomic regions which are too large to sequence.

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Why is it sometimes difficult to identify causative genes using traditional linkage analysis? Why is it sometimes difficult to identify causative genes using traditional linkage analysis ? ... If you do the DNA in this material can be amplified by _____ subjected to genetic analysis and used to identify you as the perpetrator of the crime. PCR. A nucleic acid probe is. Genetic Linkage Analysis - an overview | ScienceDirect Topics Linkage Analysis - an overview | ScienceDirect Topics Pedigree Analysis in Human Genetics: Inheritance Patterns ... Genetic linkage - Wikipedia Genetic linkage analysis is one of the principal approaches used to identify genomic regions that contain genes predisposing to disease. Linkage analysis is often performed as the first stage in the genetic investigation of a trait as it can be used to identify broad genomic regions that might contain a disease gene even in the absence of ... Tue Jun 01 1999 · Genetic linkage analysis is a powerful tool to detect the chromosomal location of disease genes ...

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